HCID 19742755, compound → HCID 57186192, compound

Participants

Reaction Steps

2.7 g 3-chloro-6-(3-ethoxy-4-methoxyphenyl)pyridazine, 1.3 g sodium cyanamide and 0.5 g benzyltriethylammonium chloride are heated at 150° C. in 30 ml N-methylpyrrolidone for 3 hours. After cooling the reaction solution is diluted with 200 ml 1N sulphuric acid and extracted 3 times with 50 ml chloroform each time. The combined extracts are dried over sodium sulphate and evaporated and the residue is boiled up in isopropanol. The crystalline product is filtered off with suction, washed with isopropanol and dried in vacuo. This gives 2.6 g (96.3%) of the title compound of m.p. 206° C.

Provenance & Evidence