18-Crown-6 → HCID 57095529, compound

Participants

Reaction Steps

3 g 3-bromo-6[4-(2-methylpropoxy)-3-methoxyphenyl]pyridazine, 1.3 g sodium cyanamide and 0.5 g 18-crown-6 are boiled under reflux in 30 ml 2-methyl-4-pentanone for 5 hours. The reaction solution is then evaporated in vacuo and the residue is boiled up briefly with 200 ml 2N sodium hydrogen sulphate solution, while stirring thoroughly, the reaction product precipitating as a fine crystalline precipitate. The precipitate is filtered off with suction and boiled up again with isopropanol, the mixture is cooled and the product is filtered off with suction and, after washing with isopropanol and petroleum spirit (b.p. 50°-70° C.), dried in vacuo. This gives 2.5 g (80.6%) of the title compound of m.p. 191° C.

Provenance & Evidence