L-Glutamic acid, N-(4-(methylamino)benzoyl)-, 1,5-diethyl ester → Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate

Participants

Role	Name	HCID	Charge
Reactant	L-Glutamic acid, N-(4-(methylamino)benzoyl)-, 1,5-diethyl ester	HCID 75413	—
Reactant	Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-L-glutamate	HCID 13691215	—
Product	Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate	HCID 13691219	—

Reaction Steps

This compound was prepared from compound (11) in a manner similar to that described for the preparation of compound (5) using the reagent quantities and conditions set out in Table A.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05236927
Source dataset	uspto-grants-1993_08
ORD ID	ord-5705b0987f464022b76c5bf1d1dcf1fb
Source note	uspto-grants-1993_08