HRID2254575

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCNc1ccc(C(=O)N[C@@H](CCC(=O)OCC)C(=O)OCC)cc1

HCID12919868

未命名化合物

HCID13691213

未命名化合物

PRODUCTS

生成物

结构：C=CCN(Cc1ccc2ncn(COC(=O)C(C)(C)C)c(=O)c2c1)c1ccc(C(=O)N[C@@H](CCC(=O)OCC)C(=O)OCC)cc1

HCID13691223

未命名化合物

PROCEDURE

实验过程

This was synthesised by reaction of the compound (4) and diethyl N-(4-(prop-2-enylamino)benzoyl)-L-glutamate Lit. T. R. Jones, A. H. Jackman, S. J. Brown, M. Jones and K. R. Harrap: Europ. J. Cancer, 17 11 (1981). For characterisation a portion was dried at 70° C./P2 05 /1 mm/10 hours to give a brittle glass.

WORKUP

后处理

customFor characterisation a portion was dried at 70° C./P2 05 /1 mm/10 hours
customto give a brittle glass

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2dd1831d072b40a2bdc43226df204faf
来源数据集: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05236927
来源说明: uspto-grants-1993_08

反应 SMILES

Br[CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][N:7]([CH2:13][O:14][C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17])[C:6]2=[O:21].[CH2:22]([NH:25][C:26]1[CH:47]=[CH:46][C:29]([C:30]([NH:32][C@H:33]([C:41]([O:43][CH2:44][CH3:45])=[O:42])[CH2:34][CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])=[O:31])=[CH:28][CH:27]=1)[CH:23]=[CH2:24]>>[O:21]=[C:6]1[C:5]2[C:10](=[CH:11][CH:12]=[C:3]([CH2:2][N:25]([CH2:22][CH:23]=[CH2:24])[C:26]3[CH:47]=[CH:46][C:29]([C:30]([NH:32][C@H:33]([C:41]([O:43][CH2:44][CH3:45])=[O:42])[CH2:34][CH2:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])=[O:31])=[CH:28][CH:27]=3)[CH:4]=2)[N:9]=[CH:8][N:7]1[CH2:13][O:14][C:15](=[O:20])[C:16]([CH3:19])([CH3:18])[CH3:17]