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HRID2254591

反应详情

EQUATION

反应方程式

HRID 2254591 的结构方程式

REACTANTS

反应物

2
结构：Cn1c(=O)ccc2cc(CBr)ccc21
HCID15199065

未命名化合物

结构：CO[C@]1(c2cc(O)cc(F)c2)CCO[C@@H](C)C1
HCID22845134

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@]1(c2cc(F)cc(OCc3ccc4c(ccc(=O)n4C)c3)c2)CCO[C@@H](C)C1
HCID10364303

未命名化合物

收率 66%

PROCEDURE

实验过程

Using the procedure described in Example 1, 6-bromomethyl-1,2-dihydro-1-methylquinolin-2-one was reacted with (2S,4R)-4-(5-fluoro-3-hydroxyphenyl)-4-methoxy-2-methyltetrahydropyran to give (2S,4R)-4-[5-fluoro-3-(1,2-dihydro-1-methyl-2-oxoquinolin-6-ylmethoxy)phenyl]-4-methoxy-2-methyltetrahydropyran in 66% yield, m.p. 91°-93° C.