HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 13990945, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2,2-Dimethoxypropane | HCID 6495 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | HCID 13990933 | HCID 13990933 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 13990945 | HCID 13990945 | — |
Reaction Steps
10.0 g of 11β-fluoroandrost-4-ene-3,17-dione [U.S. Pat. No. 3,966,713 (1976)] is stirred under reflux with 60 ml of dimethoxypropane and 1.0 g of pyridinium-4-toluenesulfonate. After 8 hours, 1 ml of pyridine is added, the mixture is diluted with ethyl acetate, washed neutral with water, and dried. The crude product is chromatographed on silica gel with an acetone-hexane gradient. Yield: 7.8 g of 11β-fluoro-3-methoxyandrosta-3,5-diene-17-one as a foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05236912 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-10061bff78d24538a0e11232c81ad017 |
| Source note | uspto-grants-1993_08 |