Lithium borohydride → HCID 19742829, compound

Participants

Reaction Steps

Methyl 2-Diphenylacetyl-5-(p-methoxyphenyl)1,2,3,4-tetrahydroisoquinoline-3-carboxylate (0.47 g, 0.93 mmoles) was placed in 50 ml of ether. LiBH4 (0.10 g, 4.5 mmoles) was added. The reaction was stirred at room temperature for 3 days. The ether was evaporated. Methanol was carefully added to quench the LiBH4. The solution was diluted with water and then extracted with dichloromethane. The extracts were dried over MgSO4 and evaporated. The material was then chromatographed using 0-4% methanol in dichloromethane to give product (0.16 g, 0.33 mmoles) in 35% yield, m.p. 57°-63° C.

Provenance & Evidence