2-Naphthalenesulfonyl chloride → HCID 86747114, compound

Participants

Reaction Steps

A mixture of 53 parts of 2-naphthalenesulfonyl chloride, 30 parts of (S)-2,2-dimethyl-1,3-dioxolane-4-methanol, 70 parts of N,N-diethylethanamine and 180 parts of ethyl acetate was stirred for 2 hours at room temperature. The reaction mixture was poured into water and the product was extracted with methylbenzene. The extract was washed with water, dried, filtered and evaporated. The residue was purified by column chromotography over silica gel using trichloromethane as eluent. The pure fractions were collected and the eluent was evaporated, yielding 62.8 parts (85.8%) of (R)-[(2,2-dimethyl-1,3-dioxolan-4-yl)-methyl]2-naphthalenesulfonate (interm. 9).

Provenance & Evidence