Methyl Isocyanate → HCID 131718075, compound

HRID 2254658Notes

Reaction equation

HRID 2254658 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[CH3:5][CH:6]([CH2:8][CH2:9][CH2:10][C@H:11]([CH2:13][CH2:14][CH2:15][C@H:16]([CH2:18][CH2:19][CH2:20]/[C:21](=[CH:23]/[CH2:24][OH:25])/[CH3:22])[CH3:17])[CH3:12])[CH3:7]>C(Cl)Cl>[CH3:1][NH:2][C:3](=[O:4])[O:25][CH2:24]/[CH:23]=[C:21](/[CH2:20][CH2:19][CH2:18][C@@H:16]([CH2:15][CH2:14][CH2:13][C@@H:11]([CH2:10][CH2:9][CH2:8][CH:6]([CH3:5])[CH3:7])[CH3:12])[CH3:17])\[CH3:22]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 5280435Phytol

Product 1

HCID 131718075HCID 131718075, compoundYield 99.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.0 g of methyl isocyanate was added to a solution of 5.0 g of phytol dissolved in 15 ml of methylene chloride. The resulting mixture was refluxed for 6 hours. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue obtained was purified by a column chromatography (eluant: benzene) to obtain 5.5 g (yield: 99.2%) of oily phytyl N-methylcarbamate.

Workup

  1. temperatureThe resulting mixture was refluxed for 6 hours
  2. customAfter the completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. customThe residue obtained
  5. customwas purified by a column chromatography (eluant: benzene)

Sources & evidence

ORD record
ord-2aceaab6b3dc4cff88d914891448b8f8
Source dataset
uspto-grants-1993_08
Patent number
US05236950

Reaction notes

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