HCID 18946473, compound → HCID 18946464, compound

HRID 2254697Notes

Reaction equation

HRID 2254697 reaction equation
[CH2:1]([C:3]1[C:8]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=2)=[C:7]([O:20]CC2C=CC=CC=2)[CH:6]=[C:5]([CH2:28][CH3:29])[N:4]=1)[CH3:2]>N1C=CC=CC=1>[CH2:1]([C:3]1[NH:4][C:5]([CH2:28][CH3:29])=[CH:6][C:7](=[O:20])[C:8]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=1)[CH3:2]

Participants

3

Reactant 1

HCID 18946473HCID 18946473, compound

Product 1

HCID 18946464HCID 18946464, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Using an analogous procedure to that described in Example 9, part (iii), but starting from compound I, there was obtained in 84% yield 2,6-diethyl-1,4-dihydro-3-(4-ethoxycarbonylphenyl)-4-oxopyridine as a solid, NMR (d6 -DMSO): 0.87,1.07(two t, 3H), 1.21(t, 3H), 1.33(t, 3H), 2.34(t, 3H), 2.53(q, 2H), 4.32(q, 2H), 6.03,6.25(two s, 1H), 7.29(d, 2H), 7.95(d, 2H); mass spectrum (chemical ionisation, ammonia): 300(M+H)+.

Sources & evidence

ORD record
ord-9f49d12681004a789e61a53295146d53
Source dataset
uspto-grants-1993_08
Patent number
US05236936

Reaction notes

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