1,4-Dioxane hydrochloride → HCID 67195491, compound

HRID 225470Notes

Reaction equation

HRID 225470 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:20].O1CCOCC1>>[ClH:20].[ClH:20].[CH3:19][N:17]([CH2:16][CH2:15][O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH3:18]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58002057HCID 58002057, compound

Product 1

HCID 67195491HCID 67195491, compound

Procedure

A mixture of 1-tert-butoxycarbonylpiperidine-4-ol, sodium hydride and DMF was stirred for 5 minutes at room temperature, then 2-chloro-N,N-dimethylethylamine was added to the resultant and further stirred for 30 minutes at room temperature to give 2-[(1-tert-butoxycarbonylpiperidine-4-yl)oxy]-N,N-dimethylethylamine. A mixture of the obtained 2-[(1-tert-butoxycarbonylpiperidine-4-yl)oxy]-N,N-dimethylethylamine and 4M HCl-dioxane solution was stirred for 7 hours at room temperature to give N,N-dimethyl-2-(piperidine-4-yloxy)ethylamine dihydrochloride.

Sources & evidence

ORD record
ord-16eb09de281244658a281e498ec0ee2a
Source dataset
uspto-grants-2009_07
Patent number
US07557112B2

Reaction notes

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