HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thioacetamide → 5-(2-Methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thioacetamide | HCID 2723949 | — |
| Reactant | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(2-Methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide | HCID 21459102 | — |
Reaction Steps
A mixture of 3.12 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone and 849.3 mg of thioacetamide are heated to boiling under reflux for 18 hours in 40 ml of ethanol. After cooling, the crystals are filtered under suction and recrystallized from methanol/isopropanol. There is obtained 5-(2-methyl-4-thiazolyl)-3-nitropyrocatechol hydrobromide of m.p. 280°-282°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05236952 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-85c4c18121184a77b4a10da4d195bb93 |
| Source note | uspto-grants-1993_08 |