HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionicotinamide → 3-Nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionicotinamide | HCID 737155 | — |
| Reactant | 2-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone | HCID 21845596 | — |
| Product | 3-Nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol | HCID 21459199 | — |
Reaction Steps
A suspension of 2.91 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone is treated with 1.31 g of thionicotinamide in 50 ml of alcohol and heated to boiling under reflux for 2 hours. After cooling to room temperature the crystals are filtered under suction and recrystallized from N,N-dimethylformamide/alcohol. There is obtained 3-nitro-5-[2-(3-pyridyl)-4-thiazolyl]pyrocatechol of m.p. 279°-281°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05236952 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-c3c7f8d274bb48ea993db0f7dfa3cc02 |
| Source note | uspto-grants-1993_08 |