HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 3-Hydroxy-1-(piperazin-1-yl)propan-1-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | Tert-butyl 4-(3-hydroxypropanoyl)piperazine-1-carboxylate | HCID 67195617 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Hydroxy-1-(piperazin-1-yl)propan-1-one hydrochloride | HCID 67199605 | — |
Reaction Steps
A mixture of 1-tert-butoxycarbonylpiperazine, 3-hydroxypropionic acid, 1-hydroxybenzotriazole (HOBt), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) and DMF was stirred for 24 hours at room temperature to give 3-(4-tert-utoxycarbonylpiperazine-1-yl)-3-oxopropane-1-ol. A mixture of the obtained 3-(4-tert-butoxycarbonylpiperazine-1-yl)-3-oxopropane-1-ol, 4M HCl-dioxane solution and MeOH was stirred for 16 hours at room temperature to give 3-oxo-3-piperazine-1-ylpropane-1-ol hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557112B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-17f35e71ef7240b79c608b3cb289a17a |
| Source note | uspto-grants-2009_07 |