Glycolic Acid → HCID 69078028, compound

Participants

Reaction Steps

A mixture of 500 mg of 2-(4-chloro-2,5-difluorophenyl)-4-piperazine-1-ylthieno[3,2-d]pyrimidine dihydrochloride, 104 mg of hydroxyacetic acid, 0.32 ml of triethylamine, 184 mg of HOBt, 261 mg of EDCI and 10 ml of DMF was stirred for two days at room temperature. 70 ml of water was added to the reaction mixture. After the precipitate was filtered and washed with water, it was dried at 50° C. under reduced pressure. The obtained solid was dissolved in 10 ml of THF and was added to 2 ml of 4M HCl-dioxane aq. The resultant was concentrated under reduced pressure to give a solid. This solid was recrystallized from EtOH-EtOAc to give 487 mg of 2-{4-[2-(4-chloro-2,5-difluorophenyl)thieno[3,2-d]pyrimidine-4-yl]piperazine-1-yl}-2-oxoethanol hydrochloride.

Provenance & Evidence