HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetic Acid → N-succinimidyl bromoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetic Acid | HCID 6227 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-succinimidyl bromoacetate | HCID 3565210 | — |
Reaction Steps
Bromoacetic acid (20 mmoles) was treated with dicyclohexyl-carbodiimide (22 mmoles, 1.1 equivalents) and N-hydroxysuccinimide (22 mmoles) in 30 ml CH2Cl2 at 4° C. according to the procedure of M. S. Bernatowicz and G. R. Matsueda (Anal. Biochem. 155:95, 1986) to give the N-succinimidyl bromoacetate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05237016 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-316e1d8932b64619972eeab06afd543f |
| Source note | uspto-grants-1993_08 |