Sodium Methoxide → HCID 15022709, compound

Participants

Reaction Conditions

Reaction Steps

293.1 g (1.692 mol) of 30% strength sodium methylate solution were added over the course of 11/2 hours to a stirred solution of 434 g (1.692 mol) of 2,6-dichloro-4-trichloromethylpyrimidine in 1 l of 1,2-dichloroethane at 0° to 5° C. The mixture was then stirred at 0° to 5° C. for 1 hour and at 25° C. for 12 hours and then extracted ×4 with water and ×3 with saturated brine. Drying over magnesium sulfate and concentration resulted in 423 g (95% of theory) of the title compound as an almost colorless oil.

Provenance & Evidence