Hydrochloric Acid → HCID 178436767, compound

Participants

Reaction Steps

4M Hydrochloric acid (1.5 ml) was added to a solution of 2,6-diethyl-4-[N-acetyl-N-(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl)methylamino]pyridine (A) (0.67 g) in 1,4-dioxan (10 ml) and the mixture was stirred for 4 hours. Volatile material was removed by evaporation and the residue purified by flash chromatography eluting with dichloromethane/methanol (17:3 v/v) to give 2,6-diethyl-4-[N-acetyl-N-(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methylamino]pyridine as a solid; NMR (d6 -DMSO): 1.17(t, 6H), 1.97(t, 3H), 2.67(q, 4H), 4.89(s, 2H), 6.95(s, 2H), 7.05(q, 4H), 7.55(m, 4H); mass spectrum (+ve FAB, benzyl alcohol/methanol): 449(M+Na)+, 427(M+H)+ ; microanalysis, found: C, 67.8; H, 6.4; N, 18.5%; C25H26N6O.0.125C4H10O requires: C, 67.5; H, 6.5; N, 18.9%.

Provenance & Evidence