Sodium Carbonate → HCID 19093694, compound

Participants

Reaction Steps

A solution of compound D (0.64 g) in concentrated sulphuric acid (3 ml) was heated at 50° C. for 1 hour. The solution was cooled to ambient temperature and added cautiously to crushed ice. The mixture was basified to pH 9 with solid sodium carbonate and the precipitate was collected by filtration to give 4-amino-3-benzoyl-6-ethyl-2-methylpyridine (B) (0.35 g) as a solid, m.p. 149°-151° C.; NMR (d6 -DMSO): 1.19(t, 3H), 1.97(s, 3H), 2.53(q, 2H), 5.78(s, 2H), 6.40(s, 1H), 7.49-7.73(m, 5H); mass spectrum (chemical ionisation, ammonia): 241(M+H)+.

Provenance & Evidence