Nitric Acid → 2-Bromo-5-nitrobenzaldehyde

HRID 2254909Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2254909
[N+:1]([O-:4])(O)=[O:2].[Br:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH:8]=[O:9]>OS(O)(=O)=O>[Br:5][C:6]1[CH:13]=[CH:12][C:11]([N+:1]([O-:4])=[O:2])=[CH:10][C:7]=1[CH:8]=[O:9]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 811292-Bromobenzaldehyde

Produkt 1

HCID 111389422-Bromo-5-nitrobenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel2×

Versuchsvorschrift

A nitrating acid prepared at -10° C. by adding 55 ml of concentrated H2SO4 to 20 ml of 98 percent HNO3 was added dropwise, in the course of 60 minutes, to a solution of 63.4 g (0.34 mole) of 2-bromobenzaldehyde in 110 ml of concentrated H2SO4 at -5° C. Stirring was continued for a further 45 minutes, after which the reaction mixture was poured onto 550 g of ice, and the precipitated solid was filtered off under suction, washed with water, then with 10 percent strength Na2CO3 solution and again with water. Drying under reduced pressure at 50° C. gave 72 g (92% of theory) of product as a yellow solid of melting point 86°-88° C.

Aufarbeitung

  1. customA nitrating acid prepared at -10° C.
  2. filtrationthe precipitated solid was filtered off under suction
  3. washwashed with water
  4. customDrying under reduced pressure at 50° C.
  5. customgave 72 g (92% of theory) of product as a yellow solid of melting point 86°-88° C.

Quellen und Nachweise

ORD-Eintrag
ord-1dba62bde5014a4db694683de5dcac08
Quelldatensatz
uspto-grants-1993_08
Patentnummer
US05237089

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