Nitric Acid → HCID 14405001, compound

HRID 2254917Notes

Reaction equation

HRID 2254917 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11].[N+:12]([O-])([OH:14])=[O:13]>C(O)(=O)C.ClCCl>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([N+:12]([O-:14])=[O:13])[C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11]

Participants

5

Reactant 2

HCID 944Nitric AcidHCID 27825072,6-dichloro-3,5-difluorophenol

Product 1

HCID 14405001HCID 14405001, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6344DichloromethaneSolvent

Procedure

20 g of 2,6-dichloro-3,5-difluorophenol are initially introduced in 70 ml of acetic acid, and 8 g of 98% strength nitric acid are added dropwise. Stirring is subsequently continued at room temperature for 2 hours, and the mixture is taken up in 150 ml of dichloromethane and washed twice with water. After the dichloromethane has been distilled off, 18 g of product remain. Purity 94% according to GC analysis.

Workup

  1. washwashed twice with water
  2. distillationAfter the dichloromethane has been distilled off

Sources & evidence

ORD record
ord-6b688792a80545e8ad7cea2452b49a28
Source dataset
uspto-grants-1993_08
Patent number
US05237086

Reaction notes

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