HCID 14405001, compound → HCID 14405003, compound

HRID 2254918Notes

Reaction equation

HRID 2254918 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[C:6]([N+:9]([O-])=O)[C:5]([F:12])=[C:4]([Cl:13])[C:3]=1[OH:14].[H][H]>CO.[Ni]>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([NH2:9])[C:5]([F:12])=[C:4]([Cl:13])[C:3]=1[OH:14]

Participants

5

Reactant 2

HCID 14405001HCID 14405001, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 14405003HCID 14405003, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

18 g of 2,6-dichloro-3,5-difluoro-4-nitrophenol are hydrogenated in 100 ml of methanol in the presence of 1.5 g of Raney nickel at 25°-45° C. and 30-50 bar of hydrogen until hydrogen is no longer taken up. The mixture is filtered, and the solution is then freed from the solvent under reduced pressure. 13 g of aminophenol remain (GC purity 98.4%); m.p. 151° C.

Workup

  1. filtrationThe mixture is filtered

Sources & evidence

ORD record
ord-7e187fb6a872415c9af619187c4f6098
Source dataset
uspto-grants-1993_08
Patent number
US05237086

Reaction notes

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