反应详情

A solution of 34 g (0.19 mol) of trans-4-butylcyclohexyl acetonitrile, 43 g (0.76 mol) of KOH, and 34 cm3 of water in 190 cm3 of ethanol was refluxed over a hot water bath until the generation of ammonia gas ceased (about 10 hours). Ammonia gas was detected using phenolphthalein test paper. The reaction solution was cooled to room temperature and ethanol was distilled off. The residue was dissolved in 100 cm3 of water. The resulting solution was poured into a beaker containing 100 g of water and 100 cm3 of concentrated hydrochloric acid. The crystals precipitated in the beaker were separated out by filtration and washed with water. The crystals were recrystallized from a solvent mixture of methanol and water to yield 37 g (0.19 mol) of trans-4-butylcyclohexyl acetic acid.

1. custom(about 10 hours)
2. distillationethanol was distilled off
3. dissolutionThe residue was dissolved in 100 cm3 of water
4. additionThe resulting solution was poured into a beaker
5. additioncontaining 100 g of water and 100 cm3 of concentrated hydrochloric acid
6. customThe crystals precipitated in the beaker
7. customwere separated out by filtration
8. washwashed with water
9. customThe crystals were recrystallized from a solvent mixture of methanol and water