p-Toluenesulfonic acid → HCID 178445608, compound

Participants

Reaction Steps

A solution of 6.1 g (0.025 mol) of 2-[2'-(trans-4"-butylcyclohexyl)ethyl]propane-1,3-diol, 5.1 g (0.025 mol) of 4-bromo-3-fluorobenzaldehyde, and g of TsOH in 125 cm3 of dichloromethane was refluxed for 5 hours over a hot water bath with a Dean-Stark trap. The solution was washed with water and the dichloromethane was distilled off. The residue was recrystallized from a solvent mixture of acetone and methanol to yield 8.4 g (0.02 mol) of 2-(4'-bromo-3'-fluorophenyl)-5-[2'-(trans-4"-butylcyclohexyl)ethyl]-1,3-dioxane.

Provenance & Evidence