HCID 178418546, compound → HCID 178445611, compound

Participants

Reaction Steps

8.4 g (0.02 mol) of 2-(4'-bromo-3'-fluorophenyl)-5-[2'-(trans-4"-butylcyclohexyl)ethyl]-1,3-dioxane and 2.7 g (0.03 mol) of CuCN were refluxed in 100 cm3 of NMP for 2 hours. The product was cooled to room temperature and 4 cm3 of EDA was added. The solution was poured into 100 cm3 of ice water, extracted with hexane, and washed with an aqueous solution of EDA and water. The hexane was distilled off. The residue was treated through a silica gel column with chloroform as the solvent and the chloroform was distilled off. The residue was recrystallized from a solvent mixture of acetone and methanol to yield 3.1 g (0.008 mol) of trans-2-(4'-cyano-3'fluorophenyl)-5-[2'-(trans-4"-butylcyclohexyl)ethyl]-1,3-dioxane. The phase transition points of this compound, measured by DSC, were: ##STR49## wherein C is the crystal phase, N is the nematic phase, and I is the isotropic liquid phase.

Provenance & Evidence