Hydrochloric Acid → HCID 178444340, compound

Participants

Reaction Steps

1.1 g of p-[trans-4-(1E-pentenyl)cyclohexyl]benzonitrile were boiled at 180° C. for 16 hours while gassing with argon in 17.5 ml of a 10 percent solution of potassium hydroxide in diethylene glycol. After cooling to room temperature the dark brown reaction mixture was diluted with 20 ml of water, made acid with 25 percent hydrochloric acid and extracted four times with 100 ml of ethylene chloride each time. The organic phases were washed twice with 80 ml of water each time, dried over magnesium suphate and active carbon and concentrated. There were obtained 1.16 g (98%) of p-[trans-4-(1E-pentenyl)cyclohexyl]benzoic acid as beige crystals; Rf-value (toluene/ethyl acetate vol. 3:1) 0.45.

Provenance & Evidence