Nitric Acid → 2-Fluoro-1,3-dimethyl-5-nitrobenzene

Participants

Reaction Steps

In 120 ml of nitric acid was dissolved 120 g of 3,5-dimethyl-4-fluorobenzene (mfd. by Columbia Organic Chemical Co., Inc.) at -10° C. over a period of 1 hour, after which the temperature was adjusted to -15° C. and the reaction was carried out with stirring for another 1 hour. After completion of the reaction, the reaction solution was poured onto ice and the yellow crystals thus precipitated were collected by filtration and subjected to distillation at atmospheric pressure to obtain 40 9 of 3,5-dimethyl-4-fluoro-1-nitrobenzene as distillate having a boiling point of 111°-112° C.

Provenance & Evidence