Acetic Anhydride → HCID 18958348, compound

HRID 2255020Notes

Reaction equation

HRID 2255020 reaction equation
[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:26](=[O:32])/[CH:27]=[CH:28]\[C:29]([OH:31])=O)([OH:3])=[O:2].C(OC(=O)C)(=O)C.C([O-])(=O)C.[Na+]>>[C:26]1(=[O:32])[N:25]([CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:1]([OH:3])=[O:2])[C:29](=[O:31])[CH:28]=[CH:27]1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 86747143HCID 86747143, compound

Product 1

HCID 18958348HCID 18958348, compound

Procedure

A mixture of N-(21-carboxyheneicosyl)maleamic acid (450 mg, 0.99 mmoles), 2.8 ml of acetic anhydride, and anhydrous sodium acetate (40.7 mg, 0.50 mmoles) was reacted at 100° C. for 1 hour. After the completion of reaction, the reaction mixture was treated in the same manner as in Example 1, to give 22-maleimidodocosanoic acid having the following properties.

Workup

  1. customwas reacted at 100° C. for 1 hour
  2. customAfter the completion of reaction
  3. additionthe reaction mixture was treated in the same manner as in Example 1

Sources & evidence

ORD record
ord-57c629cc7bee42fc933b1b6a00dd027f
Source dataset
uspto-grants-1993_08
Patent number
US05238837

Reaction notes

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