Dimethylamine → HCID 19390527, compound

Participants

Reaction Steps

To a solution of 100 ml of 33 % strength dimethylamine in absolute ethanol are added dropwise 35 g (0.2 mol) of ethyl 2-isopropyl-2-cyano-hydrazinecarboxylate. The solution is first stirred for 8 hours at room temperature and then for 1.5 hours at the reflux temperature. Concentration in a rotary evaporator gives an oily residue which slowly crystallizes on standing. Recrystallization from cyclohexane/ethyl acetate (4:1 by vol.) gives 30 g (88 % of theory) of 5-dimethylamino-1-isopropyl-1,2-dihydro-3H-1,2,4-triazol -3-one having a melting point of 111° C.

Provenance & Evidence