HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2,2-Dimethyl-4-(1-methyl-1,6-dihydro-6-oxo-3-pyridazinyl-amino)-6-cyano-3chromanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,2-Dimethyl-3,4-epoxy-6-cyanochroman | HCID 10867360 | — |
| Reactant | 6-Amino-2-methyl-2,3-dihydropyridazin-3-one | HCID 15711912 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2,2-Dimethyl-4-(1-methyl-1,6-dihydro-6-oxo-3-pyridazinyl-amino)-6-cyano-3chromanol | HCID 9949244 | — |
Reaction Steps
2.0 g of 2,2-dimethyl-3,4-epoxy-6-cyanochroman ("IIa") are added to a mixture of 1.2 g of 3-amino-1-methyl-1,6-dihydropyridazin-6-one and 0.3 g of NaH (80% strength) in 50 ml of dimethyl sulfoxide (DMSO) at 25°, and the mixture is stirred for 4 hours. Customary working-up and purification by column chromatography (ethyl acetate/methanol) give 2,2-dimethyl-4-(1-methyl-1,6-dihydro-6-oxo-3-pyridazinyl-amino)-6-cyano-3chromanol, m.p. 117°-119°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05238937 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-974faf64399e4504babfa6a4636dc1c1 |
| Source note | uspto-grants-1993_08 |