1-AMINOPYRIDIN-2(1H)-ONE → 2,2,3-Trimethyl-4-(1,2-dihydro-2-oxo-1-pyridyl-amino)-6-cyano-3-chromanol

関与物質

反応手順

A mixture of 1.1 g of 1-amino-1,2-dihydropyridin-2-one and 3.1 g of 2,2,3-trimethyl-3,4-epoxy-6-cyanochroman is heated to the melting point and stirred at this temperature for 8 hours. The residue is purified by column chromatography (dichloromethane/ethyl acetate; silica gel). 2,2,3-Trimethyl-4-(1,2-dihydro-2-oxo-1-pyridyl-amino)-6-cyano-3-chromanol, m.p. 184°-187°, is obtained.

情報源と証拠