Acetic Anhydride → 2,2-Dimethyl-3-acetoxy-4-(1-methyl-1,6-dihydro-6-oxo-3-pyridazinyl-amino)-6-cyano-3-chromene

HRID 2255048Notes

Reaction equation

HRID 2255048 reaction equation
[CH3:1][C:2]1([CH3:24])[CH:11]([OH:12])[CH:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17](=[O:20])[N:16]([CH3:21])[N:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:22]#[N:23])[CH:8]=2)[O:3]1.[C:25](OC(=O)C)(=[O:27])[CH3:26]>>[CH3:1][C:2]1([CH3:24])[C:11]([O:12][C:25](=[O:27])[CH3:26])=[C:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17](=[O:20])[N:16]([CH3:21])[N:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:22]#[N:23])[CH:8]=2)[O:3]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 99492442,2-Dimethyl-4-(1-methyl-1,6-dihydro-6-oxo-3-pyridazinyl-amino)-6-cyano-3chromanol

Product 1

HCID 678583892,2-Dimethyl-3-acetoxy-4-(1-methyl-1,6-dihydro-6-oxo-3-pyridazinyl-amino)-6-cyano-3-chromene

Procedure

2.0 g of 2,2-dimethyl-4-(1-methyl-1,6-dihydro-6-oxo-3-pyridazinyl-amino)-6-cyano-3-chromanol are boiled in 20 ml of acetic anhydride for 2 hours. Customary working-up gives 2,2-dimethyl-3-acetoxy-4-(1-methyl-1,6-dihydro-6-oxo-3-pyridazinyl-amino)-6-cyano-3-chromene, m.p. 110°-112°.

Sources & evidence

ORD record
ord-6d48d3d7e43b409ab39e89acff9d48b3
Source dataset
uspto-grants-1993_08
Patent number
US05238937

Reaction notes

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