Methyl iodide → 1-Benzyl-1-methyl-4-oxopiperidinium iodide

HRID 225505Notes

Reaction equation

HRID 225505 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][I:16]>CCOCC>[I-:16].[CH2:1]([N+:8]1([CH3:15])[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 192201-Benzyl-4-piperidone

Product 1

HCID 110780641-Benzyl-1-methyl-4-oxopiperidinium iodide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 9.79 ml of 1-benzyl-4-piperidone, 16.5 ml of methyl iodide was added and stirred for 16 hours at room temperature. To the resulting yellow suspension, approx. 10 ml of ether was added and the formed yellow solid was recovered by filtration, which solid was washed with ether and dried to provide 13.42 g of the title compound as a yellow powder.

Workup

  1. filtrationthe formed yellow solid was recovered by filtration, which solid
  2. washwas washed with ether
  3. customdried

Sources & evidence

ORD record
ord-b1574cd20814421887277b1d5546e2a3
Source dataset
uspto-grants-2009_07
Patent number
US07557117B2

Reaction notes

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