4-(Bromomethyl)-5-methyl-1,3-dioxol-2-one → HCID 14210554, compound

HRID 2255070Notes

Reaction equation

HRID 2255070 reaction equation
[Na+].[N:2]1[CH:7]=[C:6]([C:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[C:11]([O-:13])=[O:12].[Na+].[CH3:15][C:16]1[O:20][C:19](=[O:21])[O:18][C:17]=1[CH2:22]Br>CC(C)=O>[N:2]1[CH:7]=[C:6]([C:8]([O:10][CH2:15][C:16]2[O:20][C:19](=[O:21])[O:18][C:17]=2[CH3:22])=[O:9])[CH:5]=[CH:4][C:3]=1[C:11]([O:13][CH2:22][C:17]1[O:18][C:19](=[O:21])[O:20][C:16]=1[CH3:15])=[O:12]

Participants

4

Reactant 2

HCID 107741414-(Bromomethyl)-5-methyl-1,3-dioxol-2-oneHCID 67828894HCID 67828894, compound

Product 1

HCID 14210554HCID 14210554, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Analogously to Example 7, 6.3 g of pyridine-2,5-dicarboxylic acid sodium salt are reacted with 14.3 g of 5-methyl-2-oxo-1,3-dioxol-4-yl-methyl bromide and the mixture is boiled under reflux in acetone for 2.5 hours. After chromatography over silica gel with ethyl acetate as the mobile phase, the product is recrystallized from hot ethyl acetate.

Workup

  1. customAfter chromatography over silica gel with ethyl acetate as the mobile phase, the product is recrystallized from hot ethyl acetate

Sources & evidence

ORD record
ord-8f8becc2bad94aefae46d6765b579b27
Source dataset
uspto-grants-1993_08
Patent number
US05238948

Reaction notes

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