Nitrogen → HCID 19738077, compound

Participants

Reaction Steps

A solution of p-tolyltrimethyltin (1.26 g; 4.96 mmol) in dry toluene (8 mL) was degassed with a stream of N2 for ca. 5 min. To this solution under N2 was added 2-bromo-5-fluorobenzonitrile (0.901 g; 4.51 mmol) and Pd(PPh3)4 (260 mg; 5 mol%). The reaction was stirred at reflux under N2 for 12 hr and then cooled to room temperature. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo. The product was purified by flash chromatography on a silica gel column, eluting with Hex/CH2Cl2 to afford the title compound as a slightly yellow solid.

Provenance & Evidence