4'-(Bromomethyl)-2-cyanobiphenyl → HCID 67940430, compound

Participants

Reaction Steps

The quinazolinone prepared as described in Example 17 was alkylated with 4-bromomethyl-2'-cyanobiphenyl. The product was purified by MPLC Lobar C silica column eluting with 25% EtOAc/hexane. Rf 0.13 in 30% EtOAc/hexane. 1H-NMR (300 MHz, CDCl3): 8.32 (m, 1H), 7.84-7.59 (m, 7H), 5.46 (bs, 2H), 2.79 (3 line m, 2H), 1.80 (m, 2H), 1.44 (m, 2H), 0.94 (t, 3H).

Provenance & Evidence