Pyridine, 2-(trimethylstannyl)- → HCID 131718087, compound

Participants

Reaction Steps

A solution of 0.5 g (0.8 mmol) of 6-iodo-2-propyl-3-[(2'-(t-butylsulphonamido)biphen-4-yl)methyl]-quinazolin-4(3H)-one in 3 mL of dry DMF under nitrogen was treated with 0.24 g (1.1 mmol) of 2-trimethylstannylpyridine and 10 mg (0.01 mmol) bis(triphenylphophine)palladium dichloride. The solution was heated at 80°-90° C. for 2 hours to give a black solution. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography over silica gel eluting with 40% EtOAc/hexanes to give the title compound. 1H-NMR (CDCl3, 200 MHz): δ0.98 (s, 9H), 1.06 (t, 3H,), 1.78 (m, 2H), 2.76 (t, 2H,), 5.49 (bs, 2H), 7.29 (m, 7H), 8.50 (m, 8H), 7.75-7.91 (m, 2H), .8.15 (dd,1H), 8.57 (dd, 1H), 8.71 (dm, 1H), 8.82 (d, 1H).

Provenance & Evidence