HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 19741703, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | (2,2,2-Trifluoroacetyl)azanyl 2,2,2-trifluoroacetate | HCID 69634 | — |
| Reactant | HCID 19741713 | HCID 19741713 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 19741703 | HCID 19741703 | — |
Reaction Steps
A solution of methyl 4-(2-oxoethyl)-α-[(phenylcarbonyl)amino]-3-[(phenylcarbonyl)oxy]benzeneacetate from Preparation 9 above in toluene containing pyridine (2.3 eq) is treated with O,N-bistrifluoroacetyl hydroxyl amine (1.0 eq). The resulting solution is allowed to stir until no starting material remains. The reaction mixture is washed with saturated eq NaHCO3 solution, dried (MgSO4), and concentrated. The product of the formula 15 above is purified by silica gel chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05238958 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-b94d725e9c77466a896070276ef6aacd |
| Source note | uspto-grants-1993_08 |