HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → Methyl 3-hydroxy-4-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | 3-Hydroxy-4-methylbenzoic acid | HCID 68512 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl 3-hydroxy-4-methylbenzoate | HCID 354091 | — |
Reaction Steps
A solution of 3-hydroxy-4-methylbenzoic acid (26.1 g, 0.17 mol) in 200 mL of diethylether is treated with a solution of diazomethane in ether until a persistent yellow color develops. The resulting solution is stirred for 24 hours. The resulting solution is concentrated and the residue is crystallized from CH2Cl2. A white solid which is methyl 3-hydroxy-4-methylbenzoate is obtained (26.5 g, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05238958 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-70d0581add0e448db2aa7604603f0089 |
| Source note | uspto-grants-1993_08 |