Hydrochloric Acid → HCID 54515668, compound

Participants

Reaction Conditions

Reaction Steps

A solution of diethyl [[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]methyl]phosphonate (3.23 g, 6.4 mmol) from Preparation 17 in ethanol (30 mL) at 0° C. is treated with 1 mL of 1N HCl. The mixture is stirred at 0° C. for 2 hours. The solution is poured onto 500 mL EtOAc and water (50 mL). The organic phase is separated, dried (MgSO4), and concentrated. The residue is purified by silica gel chromatography (2.5% MeOH/CH2Cl2 followed by 5% MeOH/CH2Cl2). A colorless oil of diethyl [[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-(hydroxymethyl)phenyl]methyl]phosphonate is obtained (1.73 g, 69%).

Provenance & Evidence