HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 20087959, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3,4-Dimethoxyphenethyl alcohol | HCID 81911 | — |
| Reactant | 1-(4-Methylpiperazin-1-yl)pentan-3-one | HCID 20087953 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 20087959 | HCID 20087959 | 68.6% |
Reaction Steps
A mixture of 34,8 g of 3,4-dimethoxybenzeneethanol and 32 g of crude 1-(4-methylpiperazinyl)pentane-3-one in 400 ml of dioxane, which is saturated with anhydrous hydrochloric acid, was stirred at ambient temperature for 24 h. After addition of water the mixture was extracted with dichloromethane. The organic phase was washed, dried and evaporated to yield 41,5 g (68,5%) of crude 1-[2-(1-ethyl-3,4-dihydro-6,7-dimethoxy-1H-2-benzopyran-1-yl)ethyl]-4-methylpiperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05238939 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-38c25b9547fb444da3125b3eca67977f |
| Source note | uspto-grants-1993_08 |