Water → HCID 53853952, compound

Participants

Reaction Steps

To 200 mg of 3-allyloxymethyl-5-benzyloxy-2-chloro-6-isobutylpyrazine 1-oxide were added 195 μl of diisopropylethylamine, 51 mg of a Wilkinson's catalyst ##STR69## and 4 ml of water (10% volume)-ethanol. The mixture was reacted for 3 hours at 85°-90° C. The catalyst was removed by filtration to obtain 260 mg of 3-(1-propenyl)oxymethyl-5-benzyloxy-2-chloro-6-isobutylpyrazine 1-oxide (Compound B-6) [a cis/trans (about 4/3) mixture] as a colorless oily substance.

Provenance & Evidence