HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guaiacol → HCID 53662728, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guaiacol | HCID 460 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 18953958 | HCID 18953958 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 53662728 | HCID 53662728 | 90% |
Reaction Steps
A mixture of 4-(4-chlorophenyl)-2-(3-iodopropyl)oxazole (0.5 g), guaiacol (0.19 ml), potassium carbonate (0.24 g) and N,N-dimethylformamide (5 ml) was stirred for 30 minutes at 60° to 65° C. and poured into water. The precipitated crystals were collected by filtration to obtain 4-(4-chlorophenyl)-2-[3-(2-methoxyphenoxy) propyl]oxazole (0.445 g, 90%). Recrystallization from ether-hexane gave colorless prism crystals of mp 94°-95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05239080 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-958e995c820442229c514735acdd6f78 |
| Source note | uspto-grants-1993_08 |