Triethylamine → HCID 10028586, compound

Participants

Reaction Steps

Dodecyl bromide (0.386 g, 1.55 mM) was added dropwise to a solution of N-[2,6-bis(1-methylethyl) phenyl]-2H-tetrazole-5-methanesulfonamide (0.5 g, 1.55 mM), Et3N (0.157 g, 1.55 mM) in CH3CN (50 mL), and heated for 20 hours. The residue from solvent removal was redissolved in 20 mL EtOAc, washed with 0.1 N HCl, brine, and evaporated. N-[2,6-Bis(1-methylethyl) phenyl]-2-dodecyl-2H-tetrazole-5-methanesulfonamide was isolated by chromatography (0.13 g, 22%), mp 85°-86° C., along with trace amounts of N-[2,6-bis(1-methylethyl)phenyl]-1-dodecyl-1H-tetrazole-5-methanesulfonamide.

Provenance & Evidence