HCID 10453785, compound → HCID 22846631, compound

HRID 2255340Notes

Reaction equation

[NH2:1][C:2]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][C:8]([O:10]CC)=[O:9].[F:18][C:19]1[CH:47]=[CH:46][C:22]([CH:23]([N:31]2[C:39]3[C:34](=[CH:35][C:36](/[C:40](/[CH3:45])=[CH:41]/[C:42](O)=[O:43])=[CH:37][CH:38]=3)[CH:33]=[CH:32]2)[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)=[CH:21][CH:20]=1>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([CH:23]([N:31]2[C:39]3[C:34](=[CH:35][C:36](/[C:40](/[CH3:45])=[CH:41]/[C:42]([NH:1][C:2]4[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:3]=4[O:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[O:43])=[CH:37][CH:38]=3)[CH:33]=[CH:32]2)[C:22]2[CH:46]=[CH:47][C:19]([F:18])=[CH:20][CH:21]=2)=[CH:25][CH:26]=1

Participants

Reactant 2

HCID 10453785HCID 10453785, compound

HCID 19742000HCID 19742000, compound

Product 1

HCID 22846631HCID 22846631, compound

Procedure

169 mg of compound 62 was obtained in a similar manner to those described in the Examples 1 and 2 using 359 mg of ethyl 4-(2-amino-5-fluorophenoxy)butyrate and 300 mg of 3-[1-(4,4'-difluorobenzhydryl)indol-5-yl] isocrotonic acid obtained according to the procedures described in the Reference Examples 1-4.

Workup

customobtained

Sources & evidence

ORD record: ord-42a79ab257fe4ca2bb3681e83ec0c41b
Source dataset: uspto-grants-1993_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05239083

Reaction notes

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