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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225536Generated: October 29, 2026

Pyrrolidine → 5-Pyrrolidin-1-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/225536

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyrrolidineHCID 31268—
ReactantN-Boc-5-bromoisoindolineHCID 16102683—
Product5-Pyrrolidin-1-yl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl esterHCID 57753484—

Reaction Steps

Prepared in analogy to Example A3(d) from 5-Bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (CAS: 201940-08-1) and pyrrolidine. Orange solid. MS (m/e): 289.2 (M+H+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557114B2
Source datasetuspto-grants-2009_07
ORD IDord-f8116f0e757f43c3bdc7fdc110ab8229
Source noteuspto-grants-2009_07