Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4-Pyridinedicarboxylic acid | HCID 10365 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Thiomorpholine | HCID 67164 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178519758 | HCID 178519758 | — |
Reaction Steps
5 g (0.03 mol) of pyridine-2,4-dicarboxylic acid are suspended in 100 ml of toluene. 4.4 ml (0.06 mol) of thionyl chloride +1 ml of dimethylformamide are added dropwise at room temperature. The mixture is boiled under reflux for 2 hours until the resulting evolution of gas has ended and the solution has become clear. It is cooled to 0° C. and a solution of 60 ml (0.06 mol) of thiomorpholine and 10.4 ml (0.075 mol) of triethylamine in 20 ml of toluene is added dropwise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05240921 |
|---|
| Source dataset | uspto-grants-1993_08 |
|---|
| ORD ID | ord-17bb38e9a848448699fcd24929d5136c |
|---|
| Source note | uspto-grants-1993_08 |
|---|
