HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(2,4-Dichlorophenyl)-3-(1-methylpiperidin-3-yl)propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,4-Dichlorophenylacetonitrile | HCID 80566 | — |
| Reactant | 3-Chloromethyl-1-methylpiperidinium chloride | HCID 106690 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(2,4-Dichlorophenyl)-3-(1-methylpiperidin-3-yl)propionitrile | HCID 19738023 | — |
Reaction Steps
This intermediate (7.6 g.) was prepared using the procedure described in Example 14a except using 10 g. (0.054 mole) of 2,4-dichlorobenzyl cyanide, 10 g. (0.054 mole) of 3-chloromethyl-1-methylpiperidine hydrochloride, 11 g. (0.135 mole) of aqueous 50% sodium hydroxide, and 100 ml. of DMSO to yield an oil boiling 160°-165° C. at 5 mm of Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05240925 |
| Source dataset | uspto-grants-1993_08 |
| ORD ID | ord-507d7a63dffb4cb1a0879d3fb6b4dc27 |
| Source note | uspto-grants-1993_08 |