Sodium hydride → 1-[2-Cyano-2-(2-methoxyphenyl)-3-(tetrahydrofuran-2-yl)propyl]-1,2,4-triazole

Participants

Reaction Steps

This compound was prepared using the procedure described in Example 2b except using 27.0 g. (0.110 mole) of 2-(2-methoxyphenyl)-3-(tetrahydropyran-2-yl)propionitrile, 6.6 g. (0.165 mole) of 60% sodium hydride which had been washed with hexane to remove the mineral oil originally present, 19 g. (0.165 mole) of 1-(chloromethyl)-1,2,4-triazole, and 400 ml. of a 1 to 1 mixture of DMSO and DMF. The 1-[2-cyano-2-(2-methoxyphenyl)-3-(tetrahydropyran-2-yl)propyl]-1,2,4-triazole, 20.0 g. (56% yield), was obtained as a solid, melting point 120°-121° C.

Provenance & Evidence