HCID 19738100, compound → HCID 19738113, compound

Participants

Reaction Steps

A mixture of ethyl 3-methyl-8-isopropyl-2-(phenylmethyl)-2-azabicyclo[2.2.2]oct-7-ene-6-carboxylate hydrochloride (23.2 g, 63.8 mmol), ethanol (200 mL) and 10% palladium on carbon (2.3 g) was placed on a Parr hydrogenator at 44 psi of hydrogen pressure for 4 hours. The catalyst was removed by filtration and the solvent was concentrated in vacuo to afford 17.6 g (100%) of ethyl 3-methyl-8-isopropyl-2-azabicyclo[2.2.2]oct-7-ene-6-carboxylate hydrochloride as a white solid.

Provenance & Evidence